MolNFT v2 · #154968 · protein
Crystal structure of human MTH1 in complex with compound MI1030
6JVT: “Crystal structure of human MTH1 in complex with compound MI1030”. X-ray diffraction at 1.801, 1 ligand (CJR). MolNFT v2 #154968 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6JVT
- Type
- protein
- Length
- 305 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 1.801
- Source
- Homo sapiens
- UniProt
- P36639
- Ligands
- CJR
Structure
x-ray diffraction · resolution 1.801 · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 154 | — | P36639 |
| B | — | protein | 151 | — | P36639 |
Ligands and binding sites
- CJR · N4-methyl-6-[4-(oxetan-3-yl)piperazin-1-yl]pyrimidine-2,4-diamine · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6JVT · Crystal structure of human MTH1 in complex with compound MI1030 · the same entry in another collection · chain A against A, TM-score 1.00
- P36639 · AlphaFold monomer V2.0 prediction for 7,8-dihydro-8-oxoguanine triphosphatase (P36639) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P36639
- Elsewhere: RCSB PDB 6JVT · PDBe 6JVT · UniProt P36639
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