MolNFT v2 · #152581 · protein
Crystal structure of a human HDAC8 L6 loop mutant complexed with Quisinostat
6HSK: “Crystal structure of a human HDAC8 L6 loop mutant complexed with Quisinostat”. X-ray diffraction at 2.096, 3 ligands (GOK, K, ZN). MolNFT v2 #152581 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6HSK
- Type
- protein
- Length
- 728 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.096
- Source
- Homo sapiens
- UniProt
- Q9BY41
- Ligands
- GOK, K, ZN
Structure
x-ray diffraction · resolution 2.096 · 1 distinct chain.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | — | protein | 364 | — | Q9BY41 |
Ligands and binding sites
- GOK · 2-[4-[[(1-methylindol-3-yl) methylamino]methyl]piperidin-1-yl]-~{N}-oxidanyl-pyrimidine-5-carboxamide · ligand · 2 copies · chains A, B
- K · Potassium ion · metal · 4 copies · chains A, B
- ZN · Zinc ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6HSK · Crystal structure of a human HDAC8 L6 loop mutant complexed with quisinostat · the same entry in another collection · chain A against A, TM-score 1.00
- Q9BY41 · AlphaFold monomer V2.0 prediction for histone deacetylase 8 (Q9BY41) · a predicted model of the same protein · chain B against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9BY41
- Elsewhere: RCSB PDB 6HSK · PDBe 6HSK · UniProt Q9BY41
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