MolNFT v2 · #151115 · protein

Crystal structure of hMTH1 D120N in the presence of acetate

6GLT · 7,8-dihydro-8-oxoguanine triphosphatase: “Crystal structure of hMTH1 D120N in the presence of acetate”. X-ray diffraction at 1.596, 1 pocket (best druggability 0.65). MolNFT v2 #151115 on GenesisL1: 3D structure, binding sites and…

PDB: 6GLT
Type: protein
Length: 154 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 1.596
Source: Homo sapiens
Molecule: 7,8-dihydro-8-oxoguanine triphosphatase
EC: 3.6.1.55, 3.6.1.56
UniProt: P36639
Pockets: 1 · best druggability 0.65

Structure

x-ray diffraction · resolution 1.596 · 1 distinct chain · 18% helix, 46% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	7,8-dihydro-8-oxoguanine triphosphatase (EC 3.6.1.55, 3.6.1.56)	protein	154	18% helix, 46% strand	P36639

Ligands and binding sites

DMS · Dimethyl sulfoxide · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	224	0.65	0.83	30	DMS

Compared structures

6GLT · Crystal structure of HMTH1 D120N in the presence of acetate · the same entry in another collection · chain A against A, TM-score 1.00
P36639 · AlphaFold monomer V2.0 prediction for 7,8-dihydro-8-oxoguanine triphosphatase (P36639) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P36639
Elsewhere: RCSB PDB 6GLT · PDBe 6GLT · UniProt P36639

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