MolNFT v2 · #148472 · protein
IRAK4 in complex with Ponatinib
6EG9: “IRAK4 in complex with Ponatinib”. X-ray diffraction at 2.414, 3 ligands (0LI, CO, SO4). MolNFT v2 #148472 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6EG9
- Type
- protein
- Length
- 550 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.414
- Source
- Homo sapiens
- UniProt
- Q9NWZ3
- Ligands
- 0LI, CO, SO4
Structure
x-ray diffraction · resolution 2.414 · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 276 | — | Q9NWZ3 |
| B | — | protein | 274 | — | Q9NWZ3 |
Ligands and binding sites
- 0LI · 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl) phenyl}benzamide · ligand · 2 copies · chains A, B
- CO · Cobalt (II) ion · metal · 4 copies · chains A, B
- SO4 · Sulfate ion · ion · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9NWZ3
- Elsewhere: RCSB PDB 6EG9 · PDBe 6EG9 · UniProt Q9NWZ3
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