MolNFT v2 · #143147 · protein
Crystal structure of bruton's tyrosine kinase in complex with inhibitor 2e
5ZZ4: “Crystal structure of bruton's tyrosine kinase in complex with inhibitor 2e”. X-ray diffraction at 2.9, 1 ligand (9M3). MolNFT v2 #143147 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5ZZ4
- Type
- protein
- Length
- 1,574 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.9
- Source
- Homo sapiens
- UniProt
- Q06187
- Ligands
- 9M3
Structure
x-ray diffraction · resolution 2.9 · 3 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 261 | — | Q06187 |
| B, D, F | — | protein | 263 | — | Q06187 |
| C, E | — | protein | 262 | — | Q06187 |
Ligands and binding sites
- 9M3 · N-[3-(4-amino-6-{[4-(morpholine-4-carbonyl) phenyl]amino}-1,3,5-triazin-2-yl)-2-methylphenyl]-4-tert-butylbenzamide · ligand · 6 copies · chains A, B, C, D, E, F
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 5ZZ4 · Crystal structure of BRUTON'S tyrosine kinase in complex with inhibitor 2E · the same entry in another collection · chain F against F, TM-score 1.00
- Q06187 · AlphaFold monomer V2.0 prediction for tyrosine-protein kinase btk (Q06187) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q06187
- Elsewhere: RCSB PDB 5ZZ4 · PDBe 5ZZ4 · UniProt Q06187
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