MolNFT v2 · #142258 · protein

Structure of Pycnonodysostosis disease related I249T mutant of human cathepsin K

5Z5O: “Structure of Pycnonodysostosis disease related I249T mutant of human cathepsin K”. X-ray diffraction at 1.92, 3 ligands (NA, SO4, CL). MolNFT v2 #142258 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5Z5O
Type: protein
Length: 386 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 1.92
Source: Homo sapiens
UniProt: P43235
Ligands: NA, SO4, CL

Structure

x-ray diffraction · resolution 1.92 · 2 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	309	—	P43235
B	—	protein	77	—	P43235

Ligands and binding sites

NA · Sodium ion · metal · chains A
SO4 · Sulfate ion · ion · 5 copies · chains A, B
CL · Chloride ion · ion · chains A
EDO · 1,2-ethanediol · additive · 16 copies · chains A, B
GOL · Glycerol · additive · 8 copies · chains A, B
PEG · Di(hydroxyethyl)ether · additive · 7 copies · chains A, B
MPD · (4S)-2-methyl-2,4-pentanediol · additive · 3 copies · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

5Z5O · Structure of pycnonodysostosis disease related I249T mutant of human cathepsin K · the same entry in another collection · chain A against A, TM-score 1.00
P43235 · AlphaFold monomer V2.0 prediction for cathepsin K (P43235) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P43235
Elsewhere: RCSB PDB 5Z5O · PDBe 5Z5O · UniProt P43235

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