MolNFT v2 · #140004 · protein
Human thymidylate synthase with a fragment bound in the dimer interface
5X69: “Human thymidylate synthase with a fragment bound in the dimer interface”. X-ray diffraction at 2.69, 2 ligands (UMP, 7ZC). MolNFT v2 #140004 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5X69
- Type
- protein
- Length
- 1,692 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.69
- Source
- Homo sapiens
- UniProt
- P04818
- Ligands
- UMP, 7ZC
Structure
x-ray diffraction · resolution 2.69 · 6 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 287 | — | P04818 |
| B | — | protein | 286 | — | P04818 |
| C | — | protein | 277 | — | P04818 |
| D | — | protein | 285 | — | P04818 |
| E | — | protein | 276 | — | P04818 |
| F | — | protein | 281 | — | P04818 |
Ligands and binding sites
- UMP · 2'-deoxyuridine 5'-monophosphate · ligand · 4 copies · chains A, D, B, E, C, F
- 7ZC · 1-(5-methoxy-1H-indol-3-yl)-N,N-dimethyl-methanamine · ligand · 2 copies · chains A, D, B, E
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 5X69 · Human thymidylate synthase with a fragment bound in the dimer interface · the same entry in another collection · chain F against F, TM-score 1.00
- P04818 · AlphaFold monomer V2.0 prediction for thymidylate synthase (P04818) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P04818
- Elsewhere: RCSB PDB 5X69 · PDBe 5X69 · UniProt P04818
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