MolNFT v2 · #136886 · protein

Structure of a SemiSWEET Q20A mutant

5UHQ · Sugar transporter SemiSWEET: “Structure of a SemiSWEET Q20A mutant”. X-ray diffraction at 2.78, 7 pockets (best druggability 0.55). MolNFT v2 #136886 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5UHQ
Type: protein
Length: 335 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 2.78
Source: Leptospira biflexa serovar Patoc (strain Patoc 1 / ATCC 23582 / Paris)
Molecule: Sugar transporter SemiSWEET
UniProt: B0SR19
Pockets: 7 · best druggability 0.55

Structure

x-ray diffraction · resolution 2.78 · 3 distinct chains · 86% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Sugar transporter SemiSWEET	protein	93	77% helix, 0% strand	B0SR19
B, D	Sugar transporter SemiSWEET	protein	81	88% helix, 0% strand	B0SR19
C	Sugar transporter SemiSWEET	protein	80	94% helix, 0% strand	B0SR19

Pockets

7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	243	0.55	0.77	29	empty
2	228	0.52	0.75	24	empty
3	228	0.46	0.74	26	empty
4	105	0.39	0.75	22	empty
5	120	0.35	0.73	16	empty

Interfaces

4 interfaces between chains.

A–B · 1688 Å² buried · 12 hydrogen bonds · protein-protein
C–D · 1165 Å² buried · 0 hydrogen bonds · protein-protein
B–D · 768 Å² buried · 8 hydrogen bonds · protein-protein
A–D · 91 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

5UHQ · Structure of a semisweet Q20A mutant · the same entry in another collection · chain A against A, TM-score 1.00
B0SR19 · AlphaFold monomer V2.0 prediction for sugar transporter semisweet (B0SR19) · a predicted model of the same protein · chain C against A, TM-score 0.55

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt B0SR19
Elsewhere: RCSB PDB 5UHQ · PDBe 5UHQ · UniProt B0SR19

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