MolNFT v2 · #13443 · protein
Crystal structure of indole-3-glycerol phosphate syntase (IGPS)WITH reduced 1-(O-caboxyphenylamino)-1-deoxyribulose 5-phosphate (rcdrp)
1LBF · Indole-3-glycerol phosphate synthase: “Crystal structure of indole-3-glycerol phosphate syntase (IGPS)WITH reduced…”. X-ray diffraction at 2.05, 1 ligand (137), 1 pocket (best druggability 0.75). MolNFT v2 #13443 on GenesisL1: 3D…
- PDB
- 1LBF
- Type
- protein
- Length
- 247 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.05
- Source
- Sulfolobus solfataricus
- Molecule
- Indole-3-glycerol phosphate synthase
- EC
- 4.1.1.48
- UniProt
- Q06121
- Ligands
- 137
- Pockets
- 1 · best druggability 0.75
Structure
x-ray diffraction · resolution 2.05 · 1 distinct chain · 41% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Indole-3-glycerol phosphate synthase (EC 4.1.1.48) | protein | 247 | 41% helix, 17% strand | Q06121 |
Ligands and binding sites
- 137 · 1-(O-carboxy-phenylamino)-1-deoxy-D-ribulose-5-phosphate · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 171 | 0.75 | 0.91 | 32 | 137 |
Compared structures
- 1LBF · Crystal structure of indole-3-glycerol phosphate syntase (IGPS)WITH reduced… · the same entry in another collection · chain A against A, TM-score 1.00
- Q06121 · AlphaFold monomer V2.0 prediction for indole-3-glycerol phosphate synthase (Q06121) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q06121
- Elsewhere: RCSB PDB 1LBF · PDBe 1LBF · UniProt Q06121
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