MolNFT v2 · #126138 · protein
Crystal structure of human AKR1B10 complexed with NADP+ and the inhibitor MK204
5LIY: “Crystal structure of human AKR1B10 complexed with NADP+ and the inhibitor MK204”. X-ray diffraction at 2.05, 2 ligands (NAP, DQP). MolNFT v2 #126138 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5LIY
- Type
- protein
- Length
- 316 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.05
- Source
- Homo sapiens
- UniProt
- O60218
- Ligands
- NAP, DQP
Structure
x-ray diffraction · resolution 2.05 · 1 distinct chain.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| X | — | protein | 316 | — | O60218 |
Ligands and binding sites
- NAP · Nadp nicotinamide-adenine-dinucleotide phosphate · ligand · chains X
- DQP · {5-chloro-2-[(pentabromobenzyl)carbamoyl]phenoxy}acetic acid · ligand · chains X
- EDO · 1,2-ethanediol · additive · chains X
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 5LIY · Crystal structure of human AKR1B10 complexed with NADP+ and the inhibitor MK204 · the same entry in another collection · chain X against X, TM-score 1.00
- O60218 · AlphaFold monomer V2.0 prediction for aldo-keto reductase family 1 member B10 (O60218) · a predicted model of the same protein · chain X against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O60218
- Elsewhere: RCSB PDB 5LIY · PDBe 5LIY · UniProt O60218
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