MolNFT v2 · #123906 · protein
Structure of Plasmodium falciparum DXR in complex with a beta-substituted fosmidomycin analogue, LC56 and manganese
5JO0: “Structure of Plasmodium falciparum DXR in complex with a beta-substituted fosmidomycin analogue, LC56 and…”. X-ray diffraction at 1.8, 3 ligands (L56, 6LR, MN). MolNFT v2 #123906 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 5JO0
- Type
- protein
- Length
- 820 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 1.8
- Source
- Plasmodium falciparum 3D7
- UniProt
- Q8IKG4
- Ligands
- L56, 6LR, MN
Structure
x-ray diffraction · resolution 1.8 · 1 distinct chain.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | — | protein | 410 | — | Q8IKG4 |
Ligands and binding sites
- L56 · [(2R)-2-{2-[hydroxy(methyl)amino]-2-oxoethyl}-5-(3-methylphenyl)pentyl]phosphonic acid · ligand · 2 copies · chains A, B
- 6LR · morpholine · ligand · chains A
- MN · Manganese (II) ion · metal · 2 copies · chains A, B
- EDO · 1,2-ethanediol · additive · 8 copies · chains A, B
- GOL · Glycerol · additive · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 5JO0 · Structure of plasmodium falciparum dxr in complex with a beta- substituted fosmidomycin… · the same entry in another collection · chain A against A, TM-score 1.00
- Q8IKG4 · AlphaFold monomer V2.0 prediction for 1-deoxy-D-xylulose 5-phosphate reductoisomerase… · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8IKG4
- Elsewhere: RCSB PDB 5JO0 · PDBe 5JO0 · UniProt Q8IKG4
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