MolNFT v2 · #119272 · protein
Human aldehyde dehydrogenase 1A3 complexed with NAD(+) and retinoic acid
5FHZ: “Human aldehyde dehydrogenase 1A3 complexed with NAD(+) and retinoic acid”. X-ray diffraction at 2.9, 2 ligands (NAD, REA). MolNFT v2 #119272 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5FHZ
- Type
- protein
- Length
- 3,818 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.9
- Source
- Homo sapiens
- UniProt
- P47895
- Ligands
- NAD, REA
Structure
x-ray diffraction · resolution 2.9 · 8 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 489 | — | P47895 |
| B | — | protein | 475 | — | P47895 |
| C | — | protein | 489 | — | P47895 |
| D | — | protein | 488 | — | P47895 |
| E | — | protein | 478 | — | P47895 |
| F | — | protein | 449 | — | P47895 |
| G | — | protein | 462 | — | P47895 |
| H | — | protein | 488 | — | P47895 |
Ligands and binding sites
- NAD · Nicotinamide-adenine-dinucleotide · ligand · 8 copies · chains A, B, C, D, E, F, G, H
- REA · Retinoic acid · ligand · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 5FHZ · Human aldehyde dehydrogenase 1A3 complexed with NAD(+) and retinoic acid · the same entry in another collection · chain H against H, TM-score 1.00
- P47895 · AlphaFold monomer V2.0 prediction for aldehyde dehydrogenase family 1 member A3 (P47895) · a predicted model of the same protein · chain D against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P47895
- Elsewhere: RCSB PDB 5FHZ · PDBe 5FHZ · UniProt P47895
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