MolNFT v2 · #118257 · protein

MBX2931 bound structure of bacterial efflux pump.

5ENP: “MBX2931 bound structure of bacterial efflux pump.”. X-ray diffraction at 1.9, 1 ligand (5QF). MolNFT v2 #118257 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5ENP
Type: protein
Length: 2,215 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 1.9
Source: Escherichia coli (strain K12); Escherichia coli K-12; synthetic construct
UniProt: P31224
Ligands: 5QF

Structure

x-ray diffraction · resolution 1.9 · 6 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	580	—	P31224
B	—	protein	578	—	P31224
C	—	protein	578	—	P31224
D	—	protein	161	—	—
E	—	protein	156	—	—
F	—	protein	162	—	—

Ligands and binding sites

5QF · 6-[2-(3,4-dimethoxyphenyl)ethylsulfanyl]-8-[4-(2-methoxyethyl)piperazin-1-yl]-3,3-dimethyl-1,4-dihydropyrano[3,4-c]pyridine-5-carbonitrile · ligand · chains C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

5ENP · MBX2931 bound structure of bacterial efflux pump. · the same entry in another collection · chain F against F, TM-score 1.00
P31224 · AlphaFold monomer V2.0 prediction for multidrug efflux pump subunit acrb (P31224) · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P31224
Elsewhere: RCSB PDB 5ENP · PDBe 5ENP · UniProt P31224

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