MolNFT v2 · #108262 · protein

JAK3 in complex with a covalent EGFR inhibitor

4V0G: “JAK3 in complex with a covalent EGFR inhibitor”. X-ray diffraction at 3. MolNFT v2 #108262 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4V0G
Type: protein
Length: 543 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 3
Source: HOMO SAPIENS
UniProt: P52333

Structure

x-ray diffraction · resolution 3 · 2 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	269	—	P52333
B	—	protein	274	—	P52333

Compared structures

4V0G · JAK3 in complex with a covalent EGFR inhibitor · the same entry in another collection · chain A against A, TM-score 1.00
P52333 · AlphaFold monomer V2.0 prediction for tyrosine-protein kinase JAK3 (P52333) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P52333
Elsewhere: RCSB PDB 4V0G · PDBe 4V0G · UniProt P52333

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