MolNFT v1 · #99966 · protein

Crystal structure of a CRISPR protein from archaeoglobus fulgidus

4MJK: “Crystal structure of a CRISPR protein from archaeoglobus fulgidus”. X-ray diffraction, 6 pockets (best druggability 0.62). MolNFT v1 #99966 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4MJK
Type: protein
Length: 474 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: CRISPR protein
UniProt: O28407
Pockets: 6 · best druggability 0.62

Structure

x-ray diffraction · 2 distinct chains · 18% helix, 42% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	CRISPR protein	protein	239	15% helix, 43% strand	O28407
B	CRISPR protein	protein	235	20% helix, 42% strand	O28407

Pockets

6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	74	0.62	0.90	22	empty
2	136	0.55	0.82	25	empty
3	182	0.51	0.78	30	empty
4	77	0.39	0.78	25	empty
5	63	0.35	0.77	12	empty

Interfaces

1 interface between chains.

A–B · 984 Å² buried · 10 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 5 modified (engineered).

Compared structures

4MJK · Crystal structure of a CRISPR protein from Archaeoglobus fulgidus · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O28407
Elsewhere: RCSB PDB 4MJK · PDBe 4MJK · UniProt O28407

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