MolNFT v1 · #99879 · protein
Crystal structure of human filamin C domains 4-5 and gpib alpha cytoplasmic domain complex
4MGX · Filamin-C: “Crystal structure of human filamin C domains 4-5 and gpib alpha cytoplasmic domain complex”. X-ray diffraction, 1 pocket (best druggability 0.37). MolNFT v1 #99879 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 4MGX
- Type
- protein
- Length
- 190 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Filamin-C; Platelet glycoprotein ib alpha chain
- UniProt
- Q14315, P07359
- Pockets
- 1 · best druggability 0.37
Structure
x-ray diffraction · 2 distinct chains · 6% helix, 47% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Filamin-C | protein | 181 | 7% helix, 46% strand | Q14315 |
| B | Platelet glycoprotein ib alpha chain | protein | 9 | 0% helix, 67% strand | P07359 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 96 | 0.37 | 0.75 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 545 Ų buried · 14 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 4MGX · Crystal structure of human filamin C domains 4-5 and GPIB alpha cytoplasmic domain complex · the same entry in another collection · chain A against A, TM-score 1.00
- P07359 · AlphaFold monomer V2.0 prediction for platelet glycoprotein ib alpha chain (P07359) · a predicted model of the same protein · chain B against A, TM-score 0.47
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q14315
- Every structure of UniProt P07359
- Elsewhere: RCSB PDB 4MGX · PDBe 4MGX · UniProt Q14315 · UniProt P07359
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.