MolNFT v1 · #99848 · protein

Crystal structure of human CTNNBL1(RESIDUES 33~563)

4MFV · Beta-catenin-like protein 1: “Crystal structure of human CTNNBL1(RESIDUES 33~563)”. X-ray diffraction, 12 pockets (best druggability 0.81). MolNFT v1 #99848 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4MFV
Type: protein
Length: 978 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Beta-catenin-like protein 1
UniProt: Q8WYA6
Pockets: 12 · best druggability 0.81

Structure

x-ray diffraction · 1 distinct chain · 76% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Beta-catenin-like protein 1	protein	489	76% helix, 0% strand	Q8WYA6

Pockets

12 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	932	0.81	0.83	77	empty
2	420	0.63	0.78	37	empty
3	362	0.63	0.79	35	empty
4	407	0.63	0.77	59	empty
5	75	0.42	0.80	16	empty

Interfaces

1 interface between chains.

A–B · 1024 Å² buried · 5 hydrogen bonds · protein-protein

Compared structures

4MFV · Crystal structure of human CTNNBL1(residues 33~563) · the same entry in another collection · chain B against B, TM-score 1.00
Q8WYA6 · AlphaFold monomer V2.0 prediction for beta-catenin-like protein 1 (Q8WYA6) · a predicted model of the same protein · chain B against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8WYA6
Elsewhere: RCSB PDB 4MFV · PDBe 4MFV · UniProt Q8WYA6

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