MolNFT v1 · #99814 · protein
Crystal structure of the novel protein and virulence factor ship (Q99XU0) from streptococcus pyogenes
4MER · Streptococcal histidine-rich glycoprotein interacting…: “Crystal structure of the novel protein and virulence factor ship (Q99XU0) from streptococcus pyogenes”. X-ray diffraction, 1 pocket (best druggability 0.38). MolNFT v1 #99814…
- PDB
- 4MER
- Type
- protein
- Length
- 376 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Streptococcal histidine-rich glycoprotein interacting protein
- UniProt
- Q99XU0
- Pockets
- 1 · best druggability 0.38
Structure
x-ray diffraction · 4 distinct chains · 79% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Streptococcal histidine-rich glycoprotein interacting protein | protein | 96 | 80% helix, 0% strand | Q99XU0 |
| B | Streptococcal histidine-rich glycoprotein interacting protein | protein | 95 | 78% helix, 0% strand | Q99XU0 |
| C | Streptococcal histidine-rich glycoprotein interacting protein | protein | 88 | 80% helix, 0% strand | Q99XU0 |
| D | Streptococcal histidine-rich glycoprotein interacting protein | protein | 97 | 78% helix, 0% strand | Q99XU0 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 83 | 0.38 | 0.77 | 17 | empty |
Interfaces
6 interfaces between chains.
- A–B · 2821 Ų buried · 19 hydrogen bonds · protein-protein
- C–D · 2769 Ų buried · 16 hydrogen bonds · protein-protein
- B–C · 422 Ų buried · 2 hydrogen bonds · protein-protein
- A–D · 401 Ų buried · 2 hydrogen bonds · protein-protein
- B–D · 142 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 4MER · Crystal structure of the novel protein and virulence factor sHIP (Q99XU0) from… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q99XU0
- Elsewhere: RCSB PDB 4MER · PDBe 4MER · UniProt Q99XU0
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