MolNFT v1 · #99606 · protein
Crystal structure of se-met HN33/TUSC3
4M8G · Tumor suppressor candidate 3: “Crystal structure of se-met HN33/TUSC3”. X-ray diffraction, 4 pockets (best druggability 0.58). MolNFT v1 #99606 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4M8G
- Type
- protein
- Length
- 278 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tumor suppressor candidate 3
- UniProt
- Q13454
- Pockets
- 4 · best druggability 0.58
Structure
x-ray diffraction · 2 distinct chains · 40% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tumor suppressor candidate 3 | protein | 139 | 40% helix, 17% strand | Q13454 |
| B | Tumor suppressor candidate 3 | protein | 139 | 40% helix, 17% strand | Q13454 |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 159 | 0.58 | 0.82 | 31 | empty |
| 2 | 82 | 0.43 | 0.80 | 16 | empty |
| 3 | 57 | 0.41 | 0.81 | 16 | empty |
| 4 | 62 | 0.37 | 0.79 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 515 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 14 modified, 2 disulfide (engineered, disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q13454
- Elsewhere: RCSB PDB 4M8G · PDBe 4M8G · UniProt Q13454
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