MolNFT v1 · #99579 · protein
Crystal structure of the complex between human tissue factor extracellular domain and antibody 10H10 Fab fragment
4M7L: “Crystal structure of the complex between human tissue factor extracellular domain and antibody 10H10 Fab…”. X-ray diffraction, 6 pockets (best druggability 0.63). MolNFT v1 #99579 on GenesisL1: 3D structure, binding sites and…
- PDB
- 4M7L
- Type
- protein
- Length
- 637 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tissue factor; 10H10 light chain; 10H10 heavy chain
- UniProt
- P13726
- Pockets
- 6 · best druggability 0.63
Structure
x-ray diffraction · 3 distinct chains · 5% helix, 47% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| T | Tissue factor | protein | 194 | 8% helix, 51% strand | P13726 |
| L | 10H10 light chain | protein | 220 | 5% helix, 48% strand | — |
| H | 10H10 heavy chain | protein | 223 | 4% helix, 43% strand | — |
Pockets
6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 650 | 0.63 | 0.74 | 66 | empty |
| 2 | 168 | 0.50 | 0.77 | 26 | empty |
| 3 | 105 | 0.47 | 0.80 | 31 | empty |
| 4 | 117 | 0.40 | 0.75 | 24 | empty |
| 5 | 75 | 0.33 | 0.75 | 20 | empty |
Interfaces
3 interfaces between chains.
- L–H · 1977 Ų buried · 17 hydrogen bonds · protein-protein
- T–H · 743 Ų buried · 11 hydrogen bonds · protein-protein
- T–L · 494 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 7 disulfide, 1 modified (disulfide, cyclization).
Compared structures
- 4M7L · Crystal structure of the complex between human tissue factor extracellular domain and… · the same entry in another collection · chain T against T, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P13726
- Elsewhere: RCSB PDB 4M7L · PDBe 4M7L · UniProt P13726
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