MolNFT v1 · #99556 · protein
Crystal structure of the C-terminal segment of fancm in complex with FAAP24
4M6W · Fanconi anemia group M protein: “Crystal structure of the C-terminal segment of fancm in complex with FAAP24”. X-ray diffraction, 1 ligand (SO4), 4 pockets (best druggability 0.56). MolNFT v1 #99556 on GenesisL1: 3D structure…
- PDB
- 4M6W
- Type
- protein
- Length
- 388 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fanconi anemia group M protein; Fanconi anemia-associated protein of 24 kda
- EC
- 3.6.4.13
- UniProt
- Q8IYD8, Q9BTP7
- Ligands
- SO4
- Pockets
- 4 · best druggability 0.56
Structure
x-ray diffraction · 2 distinct chains · 46% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Fanconi anemia group M protein (EC 3.6.4.13) | protein | 198 | 46% helix, 16% strand | Q8IYD8 |
| B | Fanconi anemia-associated protein of 24 kda | protein | 190 | 46% helix, 16% strand | Q9BTP7 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 3 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 168 | 0.56 | 0.81 | 22 | empty |
| 2 | 80 | 0.50 | 0.84 | 19 | empty |
| 3 | 127 | 0.43 | 0.76 | 24 | empty |
| 4 | 59 | 0.37 | 0.79 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 2051 Ų buried · 21 hydrogen bonds · protein-protein
Compared structures
- 4M6W · Crystal structure of the C-terminal segment of FANCM in complex with FAAP24 · the same entry in another collection · chain A against A, TM-score 1.00
- Q8IYD8 · AlphaFold monomer V2.0 prediction for fanconi anemia group M protein (Q8IYD8) · a predicted model of the same protein · chain A against A, TM-score 0.97
- Q9BTP7 · AlphaFold monomer V2.0 prediction for fanconi anemia core complex- associated protein 24… · a predicted model of the same protein · chain B against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8IYD8
- Every structure of UniProt Q9BTP7
- Elsewhere: RCSB PDB 4M6W · PDBe 4M6W · UniProt Q8IYD8 · UniProt Q9BTP7
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