MolNFT v1 · #99546 · protein

Crystal structure of anti-il-23 antibody CNTO1959 at pH 9.5

4M6M · CNTO1959 light chain: “Crystal structure of anti-il-23 antibody CNTO1959 at pH 9.5”. X-ray diffraction, 3 pockets (best druggability 0.60). MolNFT v1 #99546 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4M6M
Type: protein
Length: 431 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: CNTO1959 light chain; CNTO1959 heavy chain
Pockets: 3 · best druggability 0.60

Structure

x-ray diffraction · 2 distinct chains · 7% helix, 51% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
L	CNTO1959 light chain	protein	216	6% helix, 49% strand	—
H	CNTO1959 heavy chain	protein	215	8% helix, 53% strand	—

Ligands and binding sites

GOL · Glycerol · additive · chains L
MLA · Malonic acid · additive · chains L
PEG · Di(hydroxyethyl)ether · additive · chains H

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	515	0.60	0.74	63	empty
2	225	0.51	0.76	47	empty
3	95	0.33	0.73	18	empty

Interfaces

1 interface between chains.

L–H · 1918 Å² buried · 14 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 5 disulfide (disulfide).

Compared structures

4M6M · Crystal structure of anti-IL-23 antibody CNTO1959 at pH 9.5 · the same entry in another collection · chain L against L, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 4M6M · PDBe 4M6M

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