MolNFT v1 · #99268 · protein

Crystal structure of human PRS1 E43T mutant

4LYG · Ribose-phosphate pyrophosphokinase 1: “Crystal structure of human PRS1 E43T mutant”. X-ray diffraction, 1 ligand (SO4), 7 pockets (best druggability 0.73). MolNFT v1 #99268 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 4LYG
Type: protein
Length: 614 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ribose-phosphate pyrophosphokinase 1
EC: 2.7.6.1
UniProt: P60891
Ligands: SO4
Pockets: 7 · best druggability 0.73

Structure

x-ray diffraction · 2 distinct chains · 35% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ribose-phosphate pyrophosphokinase 1 (EC 2.7.6.1)	protein	304	35% helix, 25% strand	P60891
B	Ribose-phosphate pyrophosphokinase 1 (EC 2.7.6.1)	protein	310	35% helix, 26% strand	P60891

Ligands and binding sites

SO4 · Sulfate ion · ion · 5 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	209	0.73	0.89	40	empty
2	141	0.62	0.86	30	empty
3	141	0.52	0.81	24	empty
4	120	0.49	0.80	24	empty
5	194	0.47	0.75	37	SO4

Interfaces

1 interface between chains.

A–B · 2009 Å² buried · 34 hydrogen bonds · protein-protein

Compared structures

4LYG · Crystal structure of human PRS1 E43T mutant · the same entry in another collection · chain A against A, TM-score 1.00
P60891 · AlphaFold monomer V2.0 prediction for ribose-phosphate pyrophosphokinase 1 (P60891) · a predicted model of the same protein · chain B against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P60891
Elsewhere: RCSB PDB 4LYG · PDBe 4LYG · UniProt P60891

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.