MolNFT v1 · #99221 · protein
Crystal structure of MYO5A globular tail domain
4LX1 · Unconventional myosin-va: “Crystal structure of MYO5A globular tail domain”. X-ray diffraction, 1 ligand (SO4), 5 pockets (best druggability 0.48). MolNFT v1 #99221 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4LX1
- Type
- protein
- Length
- 720 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Unconventional myosin-va
- UniProt
- Q9Y4I1
- Ligands
- SO4
- Pockets
- 5 · best druggability 0.48
Structure
x-ray diffraction · 2 distinct chains · 65% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Unconventional myosin-va | protein | 360 | 65% helix, 2% strand | Q9Y4I1 |
| B | Unconventional myosin-va | protein | 360 | 65% helix, 2% strand | Q9Y4I1 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 8 copies · chains A, B
- EDO · 1,2-ethanediol · additive · chains A
- TRS · 2-amino-2-hydroxymethyl-propane-1,3-diol · additive · chains A
- GOL · Glycerol · additive · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 259 | 0.48 | 0.73 | 30 | empty |
| 2 | 209 | 0.47 | 0.74 | 33 | empty |
| 3 | 100 | 0.40 | 0.77 | 20 | empty |
| 4 | 69 | 0.39 | 0.79 | 18 | empty |
| 5 | 57 | 0.33 | 0.77 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 822 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9Y4I1
- Elsewhere: RCSB PDB 4LX1 · PDBe 4LX1 · UniProt Q9Y4I1
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