MolNFT v1 · #99134 · protein
The crystal structure of the P132A, Y133G mutant of pyrococcus furiosus phosphoglucose isomerase in complex with manganese and 5- phospho-D-arabinonate.
4LUK · Glucose-6-phosphate isomerase: “The crystal structure of the P132A, Y133G mutant of pyrococcus furiosus phosphoglucose isomerase in complex…”. X-ray diffraction, 2 ligands (PA5, MN), 1 pocket (best druggability 0.63). MolNFT v1…
- PDB
- 4LUK
- Type
- protein
- Length
- 189 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glucose-6-phosphate isomerase
- EC
- 5.3.1.9
- UniProt
- P83194
- Ligands
- PA5, MN
- Pockets
- 1 · best druggability 0.63
Structure
x-ray diffraction · 1 distinct chain · 10% helix, 42% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glucose-6-phosphate isomerase (EC 5.3.1.9) | protein | 189 | 10% helix, 42% strand | P83194 |
Ligands and binding sites
- PA5 · 5-phosphoarabinonic acid · ligand · chains A
- MN · Manganese (II) ion · metal · chains A
- EDO · 1,2-ethanediol · additive · 4 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 139 | 0.63 | 0.86 | 25 | PA5, EDO |
Compared structures
- 4LUK · The crystal structure of the P132A, Y133G mutant of Pyrococcus furiosus phosphoglucose… · the same entry in another collection · chain A against A, TM-score 1.00
- P83194 · AlphaFold monomer V2.0 prediction for glucose-6-phosphate isomerase (P83194) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P83194
- Elsewhere: RCSB PDB 4LUK · PDBe 4LUK · UniProt P83194
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