MolNFT v1 · #99109 · protein

Bacterial sodium channel, HIS245GLY mutant, I222 space group

4LTR · Ion transport protein: “Bacterial sodium channel, HIS245GLY mutant, I222 space group”. X-ray diffraction, 3 pockets (best druggability 0.79). MolNFT v1 #99109 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4LTR
Type: protein
Length: 544 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ion transport protein
UniProt: Q0ABW0
Pockets: 3 · best druggability 0.79

Structure

x-ray diffraction · 1 distinct chain · 77% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Ion transport protein	protein	136	77% helix, 0% strand	Q0ABW0

Pockets

3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1129	0.79	0.80	78	empty
2	1107	0.74	0.77	78	empty
3	97	0.52	0.82	19	empty

Interfaces

6 interfaces between chains.

B–C · 1443 Å² buried · 9 hydrogen bonds · protein-protein
A–B · 1416 Å² buried · 9 hydrogen bonds · protein-protein
A–D · 1368 Å² buried · 8 hydrogen bonds · protein-protein
C–D · 1308 Å² buried · 10 hydrogen bonds · protein-protein
A–C · 53 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

4LTR · Bacterial sodium channel, His245Gly mutant, I222 space group · the same entry in another collection · chain C against C, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q0ABW0
Elsewhere: RCSB PDB 4LTR · PDBe 4LTR · UniProt Q0ABW0

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