MolNFT v1 · #99042 · protein

Crystal structure of glyoxalase III (orf 19.251) from candida albicans

4LRU · Glyoxalase III (glutathione-independent): “Crystal structure of glyoxalase III (orf 19.251) from candida albicans”. X-ray diffraction, 1 pocket (best druggability 0.48). MolNFT v1 #99042 on GenesisL1: 3D structure, binding sites and…

PDB: 4LRU
Type: protein
Length: 239 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Glyoxalase III (glutathione-independent)
EC: 4.2.1.130
UniProt: Q5AF03
Pockets: 1 · best druggability 0.48

Structure

x-ray diffraction · 1 distinct chain · 41% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Glyoxalase III (glutathione-independent) (EC 4.2.1.130)	protein	239	41% helix, 18% strand	Q5AF03

Ligands and binding sites

EDO · 1,2-ethanediol · additive · chains A
ACT · Acetate ion · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	60	0.48	0.85	16	empty

Compared structures

4LRU · Crystal structure of glyoxalase III (Orf 19.251) from Candida albicans · the same entry in another collection · chain A against A, TM-score 1.00
Q5AF03 · AlphaFold monomer V2.0 prediction for glyoxalase 3 (Q5AF03) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5AF03
Elsewhere: RCSB PDB 4LRU · PDBe 4LRU · UniProt Q5AF03

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