MolNFT v1 · #99036 · protein

Ontogeny of recognition specificity and functionality for the anti-HIV antibody 4E10

4LRN · Gep 1 heavy chain: “Ontogeny of recognition specificity and functionality for the anti-HIV antibody 4E10”. X-ray diffraction, 2 pockets (best druggability 0.43). MolNFT v1 #99036 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 4LRN
Type: protein
Length: 225 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Gep 1 heavy chain; Gep 1 light chain
Pockets: 2 · best druggability 0.43

Structure

x-ray diffraction · 2 distinct chains · 5% helix, 48% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
H	Gep 1 heavy chain	protein	114	5% helix, 48% strand	—
L	Gep 1 light chain	protein	111	5% helix, 49% strand	—

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	135	0.43	0.76	25	empty
2	123	0.40	0.74	19	empty

Interfaces

1 interface between chains.

H–L · 714 Å² buried · 3 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

4LRN · Ontogeny of recognition specificity and functionality for the anti-HIV antibody 4E10 · the same entry in another collection · chain H against H, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 4LRN · PDBe 4LRN

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