MolNFT v1 · #98838 · protein

Structure of redesigned IGG1 first constant and lambda domains (CH1:CLAMBDA constant redesign 1, CRD1) at 1.75A

4LLM · Ig gamma-1 chain C region: “Structure of redesigned IGG1 first constant and lambda domains (CH1:CLAMBDA constant redesign 1, CRD1) at…”. X-ray diffraction, 1 pocket (best druggability 0.31). MolNFT v1 #98838 on GenesisL1: 3D…

PDB: 4LLM
Type: protein
Length: 202 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ig gamma-1 chain C region; Ig lambda-2 chain C region
UniProt: P01857, P0CG05
Pockets: 1 · best druggability 0.31

Structure

x-ray diffraction · 2 distinct chains · 11% helix, 53% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ig gamma-1 chain C region	protein	101	12% helix, 53% strand	P01857
B	Ig lambda-2 chain C region	protein	101	11% helix, 53% strand	P0CG05

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	66	0.31	0.75	18	empty

Interfaces

1 interface between chains.

A–B · 947 Å² buried · 9 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

4LLM · Structure of redesigned IgG1 first constant and lambda domains (CH1:Clambda constant… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P01857
Every structure of UniProt P0CG05
Elsewhere: RCSB PDB 4LLM · PDBe 4LLM · UniProt P01857 · UniProt P0CG05

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.