MolNFT v1 · #98829 · protein

Structure of wild-type IGG1 antibody heavy chain constant domain 1 and light chain lambda constant domain (IGG1 CH1:CLAMBDA) at 1.19A

4LLD · Ig gamma-1 chain C region: “Structure of wild-type IGG1 antibody heavy chain constant domain 1 and light chain lambda constant domain…”. X-ray diffraction, 2 pockets (best druggability 0.40). MolNFT v1 #98829 on GenesisL1: 3D…

PDB: 4LLD
Type: protein
Length: 200 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ig gamma-1 chain C region; Ig lambda-2 chain C region
UniProt: P01857, P0CG05
Pockets: 2 · best druggability 0.40

Structure

x-ray diffraction · 2 distinct chains · 10% helix, 54% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ig gamma-1 chain C region	protein	99	9% helix, 54% strand	P01857
B	Ig lambda-2 chain C region	protein	101	11% helix, 53% strand	P0CG05

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	105	0.40	0.76	26	empty
2	75	0.38	0.78	18	empty

Interfaces

1 interface between chains.

A–B · 961 Å² buried · 8 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

4LLD · Structure of wild-type IgG1 antibody heavy chain constant domain 1 and light chain lambda… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P01857
Every structure of UniProt P0CG05
Elsewhere: RCSB PDB 4LLD · PDBe 4LLD · UniProt P01857 · UniProt P0CG05

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