MolNFT v1 · #98826 · protein
Crystal structure of D3D4 domain of the LILRB2 molecule
4LLA · Leukocyte immunoglobulin-like receptor subfamily B member 2: “Crystal structure of D3D4 domain of the LILRB2 molecule”. X-ray diffraction, 4 pockets (best druggability 0.73). MolNFT v1 #98826 on GenesisL1: 3D structure, binding…
- PDB
- 4LLA
- Type
- protein
- Length
- 594 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Leukocyte immunoglobulin-like receptor subfamily B member 2
- UniProt
- Q8N423
- Pockets
- 4 · best druggability 0.73
Structure
x-ray diffraction · 1 distinct chain · 3% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Leukocyte immunoglobulin-like receptor subfamily B member 2 | protein | 198 | 3% helix, 50% strand | Q8N423 |
Pockets
4 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 691 | 0.73 | 0.80 | 69 | empty |
| 2 | 475 | 0.67 | 0.79 | 56 | empty |
| 3 | 210 | 0.57 | 0.80 | 23 | empty |
| 4 | 282 | 0.52 | 0.74 | 34 | empty |
Interfaces
3 interfaces between chains.
- A–B · 469 Ų buried · 5 hydrogen bonds · protein-protein
- A–C · 318 Ų buried · 2 hydrogen bonds · protein-protein
- B–C · 186 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 4LLA · Crystal structure of D3D4 domain of the LILRB2 molecule · the same entry in another collection · chain A against A, TM-score 1.00
- Q8N423 · AlphaFold monomer V2.0 prediction for leukocyte immunoglobulin-like receptor subfamily B… · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8N423
- Elsewhere: RCSB PDB 4LLA · PDBe 4LLA · UniProt Q8N423
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