MolNFT v1 · #98824 · protein
Complex of carboxy terminal domain of MYO4P and SHE3P middle fragment
4LL8 · Myosin-4: “Complex of carboxy terminal domain of MYO4P and SHE3P middle fragment”. X-ray diffraction, 7 pockets (best druggability 0.65). MolNFT v1 #98824 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4LL8
- Type
- protein
- Length
- 660 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Myosin-4; SWI5-dependent ho expression protein 3
- UniProt
- P32492, P38272
- Pockets
- 7 · best druggability 0.65
Structure
x-ray diffraction · 3 distinct chains · 71% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Myosin-4 | protein | 428 | 61% helix, 0% strand | P32492 |
| E | SWI5-dependent ho expression protein 3 | protein | 119 | 92% helix, 0% strand | P38272 |
| B | SWI5-dependent ho expression protein 3 | protein | 113 | 86% helix, 0% strand | P38272 |
Pockets
7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 114 | 0.65 | 0.88 | 36 | empty |
| 2 | 305 | 0.59 | 0.77 | 36 | empty |
| 3 | 124 | 0.41 | 0.76 | 15 | empty |
| 4 | 70 | 0.37 | 0.78 | 16 | empty |
| 5 | 63 | 0.36 | 0.78 | 17 | empty |
Interfaces
3 interfaces between chains.
- E–B · 3151 Ų buried · 12 hydrogen bonds · protein-protein
- A–E · 1282 Ų buried · 9 hydrogen bonds · protein-protein
- A–B · 809 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 4LL8 · Complex of carboxy terminal domain of Myo4p and She3p middle fragment · the same entry in another collection · chain A against A, TM-score 1.00
- P32492 · AlphaFold monomer V2.0 prediction for myosin-4 (P32492) · a predicted model of the same protein · chain A against A, TM-score 0.86
- P38272 · AlphaFold monomer V2.0 prediction for SWI5-dependent ho expression protein 3 (P38272) · a predicted model of the same protein · chain B against A, TM-score 0.85
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P32492
- Every structure of UniProt P38272
- Elsewhere: RCSB PDB 4LL8 · PDBe 4LL8 · UniProt P32492 · UniProt P38272
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.