MolNFT v1 · #98796 · protein

An antibody against the C-terminal domain of PCSK9 lowers LDL cholesterol levels in vivo

4LKC · Fab fragment of PCSK9 antibody: “An antibody against the C-terminal domain of PCSK9 lowers LDL cholesterol levels in vivo”. X-ray diffraction, 5 pockets (best druggability 0.61). MolNFT v1 #98796 on GenesisL1: 3D structure, binding…

PDB: 4LKC
Type: protein
Length: 442 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fab fragment of PCSK9 antibody
Pockets: 5 · best druggability 0.61

Structure

x-ray diffraction · 2 distinct chains · 7% helix, 52% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Fab fragment of PCSK9 antibody	protein	213	6% helix, 51% strand	—
B	Fab fragment of PCSK9 antibody	protein	229	8% helix, 53% strand	—

Pockets

5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	532	0.61	0.74	51	empty
2	307	0.55	0.75	37	empty
3	68	0.51	0.86	22	empty
4	76	0.41	0.79	16	empty
5	64	0.28	0.73	18	empty

Interfaces

1 interface between chains.

A–B · 1791 Å² buried · 13 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

4LKC · An Antibody Against the C-terminal Domain of PCSK9 lowers LDL Cholesterol Levels in vivo · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 4LKC · PDBe 4LKC

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