MolNFT v1 · #98729 · protein
Crystal structures of LGR4 and its complex with R-SPONDIN1
4LI2 · Leucine-rich repeat-containing G-protein coupled receptor 4: “Crystal structures of LGR4 and its complex with R-SPONDIN1”. X-ray diffraction, 5 pockets (best druggability 0.69). MolNFT v1 #98729 on GenesisL1: 3D structure, binding…
- PDB
- 4LI2
- Type
- protein
- Length
- 525 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Leucine-rich repeat-containing G-protein coupled receptor 4; R-spondin-1
- UniProt
- B0BLW3, Q2MKA7
- Pockets
- 5 · best druggability 0.69
Structure
x-ray diffraction · 2 distinct chains · 2% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Leucine-rich repeat-containing G-protein coupled receptor 4 | protein | 422 | 3% helix, 18% strand | B0BLW3 |
| B | R-spondin-1 | protein | 103 | 0% helix, 33% strand | Q2MKA7 |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 365 | 0.69 | 0.82 | 39 | empty |
| 2 | 406 | 0.66 | 0.80 | 57 | empty |
| 3 | 86 | 0.46 | 0.81 | 16 | empty |
| 4 | 112 | 0.40 | 0.76 | 21 | empty |
| 5 | 53 | 0.29 | 0.75 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 1042 Ų buried · 8 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 11 disulfide (disulfide).
Compared structures
- 4LI2 · Crystal Structures of Lgr4 and its complex with R-spondin1 · the same entry in another collection · chain A against A, TM-score 1.00
- B0BLW3 · AlphaFold monomer V2.0 prediction for leucine-rich repeat-containing G-protein coupled… · a predicted model of the same protein · chain A against A, TM-score 0.90
- Q2MKA7 · AlphaFold monomer V2.0 prediction for R-spondin-1 (Q2MKA7) · a predicted model of the same protein · chain B against A, TM-score 0.86
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt B0BLW3
- Every structure of UniProt Q2MKA7
- Elsewhere: RCSB PDB 4LI2 · PDBe 4LI2 · UniProt B0BLW3 · UniProt Q2MKA7
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