MolNFT v1 · #98383 · protein

Crystal structure mutant H77A of human hd domain-containing protein 2, genomics consortium (nesg) target HR6723

4L7W: “Crystal structure mutant H77A of human hd domain-containing protein 2, genomics consortium (nesg) target…”. X-ray diffraction, 1 ligand (MG), 1 pocket (best druggability 0.60). MolNFT v1 #98383 on GenesisL1: 3D structure, binding…

PDB: 4L7W
Type: protein
Length: 188 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Hd domain-containing protein 2
UniProt: Q7Z4H3
Ligands: MG
Pockets: 1 · best druggability 0.60

Structure

x-ray diffraction · 1 distinct chain · 71% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Hd domain-containing protein 2	protein	188	71% helix, 1% strand	Q7Z4H3

Ligands and binding sites

MG · Magnesium ion · metal · 5 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	320	0.60	0.78	34	MG

Modifications

Observed in the structure: 7 modified (engineered).

Compared structures

4L7W · Crystal structure mutant H77A of human HD domain-containing protein 2, Genomics… · the same entry in another collection · chain A against A, TM-score 1.00
Q7Z4H3 · AlphaFold monomer V2.0 prediction for 5'-deoxynucleotidase HDDC2 (Q7Z4H3) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q7Z4H3
Elsewhere: RCSB PDB 4L7W · PDBe 4L7W · UniProt Q7Z4H3

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