MolNFT v1 · #98298 · protein
Crystal structure of the 3-mbt repeat domain of L3MBTL3 and UNC2533 complex
4L59 · LETHAL(3)MALIGNANT brain tumor-like protein 3: “Crystal structure of the 3-mbt repeat domain of L3MBTL3 and UNC2533 complex”. X-ray diffraction, 3 ligands (1VZ, UNX, SO4), 2 pockets (best druggability 0.73). MolNFT v1 #98298 on…
- PDB
- 4L59
- Type
- protein
- Length
- 307 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- LETHAL(3)MALIGNANT brain tumor-like protein 3
- UniProt
- Q96JM7
- Ligands
- 1VZ, UNX, SO4
- Pockets
- 2 · best druggability 0.73
Structure
x-ray diffraction · 1 distinct chain · 20% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | LETHAL(3)MALIGNANT brain tumor-like protein 3 | protein | 307 | 20% helix, 30% strand | Q96JM7 |
Ligands and binding sites
- 1VZ · 4-(pyrrolidin-1-yl)-1-{4-[2-(pyrrolidin-1-yl)ethyl]phenyl}piperidine · ligand · chains A
- UNX · Unknown atom or ion · ion · 12 copies · chains A
- SO4 · Sulfate ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 837 | 0.73 | 0.78 | 73 | empty |
| 2 | 50 | 0.31 | 0.77 | 14 | UNX |
Compared structures
- 4L59 · Crystal structure of the 3-MBT repeat domain of L3MBTL3 and UNC2533 complex · the same entry in another collection · chain A against A, TM-score 1.00
- Q96JM7 · AlphaFold monomer V2.0 prediction for LETHAL(3)MALIGNANT brain tumor- like protein 3… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q96JM7
- Elsewhere: RCSB PDB 4L59 · PDBe 4L59 · UniProt Q96JM7
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