MolNFT v1 · #98279 · protein
Methionine adenosyltransferase
4L4Q · S-adenosylmethionine synthase: “Methionine adenosyltransferase”. X-ray diffraction, 19 pockets (best druggability 0.84). MolNFT v1 #98279 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4L4Q
- Type
- protein
- Length
- 1,607 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- S-adenosylmethionine synthase
- EC
- 2.5.1.6
- UniProt
- Q5JF22
- Pockets
- 19 · best druggability 0.84
Structure
x-ray diffraction · 2 distinct chains · 36% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, D | S-adenosylmethionine synthase (EC 2.5.1.6) | protein | 402 | 36% helix, 29% strand | Q5JF22 |
| B | S-adenosylmethionine synthase (EC 2.5.1.6) | protein | 401 | 36% helix, 27% strand | Q5JF22 |
Pockets
19 pockets found on a 1 Å grid, 14 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 390 | 0.84 | 0.93 | 36 | empty |
| 2 | 1132 | 0.82 | 0.83 | 139 | empty |
| 3 | 869 | 0.76 | 0.79 | 68 | empty |
| 4 | 1091 | 0.75 | 0.78 | 90 | empty |
| 5 | 501 | 0.74 | 0.83 | 53 | empty |
Interfaces
6 interfaces between chains.
- A–B · 2742 Ų buried · 37 hydrogen bonds · protein-protein
- C–D · 2677 Ų buried · 34 hydrogen bonds · protein-protein
- A–C · 1226 Ų buried · 8 hydrogen bonds · protein-protein
- B–D · 1225 Ų buried · 9 hydrogen bonds · protein-protein
- A–D · 238 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5JF22
- Elsewhere: RCSB PDB 4L4Q · PDBe 4L4Q · UniProt Q5JF22
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