MolNFT v1 · #98241 · protein
Structure of the microtubule associated protein PRC1 (protein regulator of cytokinesis 1)
4L3I: “Structure of the microtubule associated protein PRC1 (protein regulator of cytokinesis 1)”. X-ray diffraction, 6 pockets (best druggability 0.69). MolNFT v1 #98241 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4L3I
- Type
- protein
- Length
- 892 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein regulator of cytokinesis 1
- UniProt
- O43663
- Pockets
- 6 · best druggability 0.69
Structure
x-ray diffraction · 2 distinct chains · 76% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein regulator of cytokinesis 1 | protein | 449 | 77% helix, 0% strand | O43663 |
| B | Protein regulator of cytokinesis 1 | protein | 443 | 76% helix, 0% strand | O43663 |
Pockets
6 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 363 | 0.69 | 0.81 | 33 | empty |
| 2 | 211 | 0.68 | 0.85 | 37 | empty |
| 3 | 168 | 0.62 | 0.84 | 23 | empty |
| 4 | 203 | 0.54 | 0.78 | 28 | empty |
| 5 | 84 | 0.51 | 0.84 | 26 | empty |
Interfaces
1 interface between chains.
- A–B · 1841 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 26 modified (engineered).
Compared structures
- 4L3I · Structure of the microtubule associated protein PRC1 (Protein Regulator of Cytokinesis 1) · the same entry in another collection · chain A against A, TM-score 1.00
- O43663 · AlphaFold monomer V2.0 prediction for protein regulator of cytokinesis 1 (O43663) · a predicted model of the same protein · chain B against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O43663
- Elsewhere: RCSB PDB 4L3I · PDBe 4L3I · UniProt O43663
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