MolNFT v1 · #97979 · protein
2H2 Fab fragment of immature dengue virus
4KVC · Ig heavy chain V region mopc 21, igh protein: “2H2 Fab fragment of immature dengue virus”. X-ray diffraction, 4 pockets (best druggability 0.64). MolNFT v1 #97979 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4KVC
- Type
- protein
- Length
- 432 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ig heavy chain V region mopc 21, igh protein; Ig kappa chain V-V region mopc 21…
- UniProt
- P01783, Q6PIP8, P01634, Q7TS98
- Pockets
- 4 · best druggability 0.64
Structure
x-ray diffraction · 2 distinct chains · 6% helix, 55% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | Ig heavy chain V region mopc 21, igh protein | protein | 220 | 7% helix, 54% strand | P01783, Q6PIP8 |
| L | Ig kappa chain V-V region mopc 21, anti-colorectal carcinoma light chain | protein | 212 | 5% helix, 56% strand | P01634, Q7TS98 |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 633 | 0.64 | 0.75 | 64 | empty |
| 2 | 120 | 0.47 | 0.79 | 24 | empty |
| 3 | 75 | 0.32 | 0.74 | 15 | empty |
| 4 | 58 | 0.27 | 0.73 | 14 | empty |
Interfaces
1 interface between chains.
- H–L · 1904 Ų buried · 12 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01783
- Every structure of UniProt Q6PIP8
- Every structure of UniProt P01634
- Every structure of UniProt Q7TS98
- Elsewhere: RCSB PDB 4KVC · PDBe 4KVC · UniProt P01783 · UniProt Q6PIP8 · UniProt P01634 · UniProt Q7TS98
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