MolNFT v1 · #97916 · protein

Fab fragment of HIV vaccine-elicited CD4BS-directed antibody, GE148, from non-human primate

4KTE · GE148 heavy chain Fab: “Fab fragment of HIV vaccine-elicited CD4BS-directed antibody, GE148, from non-human primate”. X-ray diffraction, 1 ligand (SO4), 2 pockets (best druggability 0.60). MolNFT v1 #97916 on GenesisL1: 3D…

PDB: 4KTE
Type: protein
Length: 436 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: GE148 heavy chain Fab; GE148 light chain Fab
Ligands: SO4
Pockets: 2 · best druggability 0.60

Structure

x-ray diffraction · 2 distinct chains · 7% helix, 54% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
H	GE148 heavy chain Fab	protein	219	7% helix, 55% strand	—
L	GE148 light chain Fab	protein	217	7% helix, 53% strand	—

Ligands and binding sites

SO4 · Sulfate ion · ion · 3 copies · chains H, L
GOL · Glycerol · additive · chains H

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	540	0.60	0.74	58	empty
2	54	0.29	0.75	16	empty

Interfaces

1 interface between chains.

H–L · 1754 Å² buried · 16 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide, 2 modified (disulfide, cyclization).

Compared structures

4KTE · Fab fragment of HIV vaccine-elicited CD4bs-directed antibody, GE148, from non-human… · the same entry in another collection · chain H against H, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 4KTE · PDBe 4KTE

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.