MolNFT v1 · #9790 · protein

C-terminal domain of mouse brain tubby protein bound to phosphatidylinositol 4,5-bis-phosphate

1I7E: “C-terminal domain of mouse brain tubby protein bound to phosphatidylinositol 4,5-bis-phosphate”. X-ray diffraction, 1 ligand (IBS), 2 pockets (best druggability 0.54). MolNFT v1 #9790 on GenesisL1: 3D structure, binding sites and…

PDB: 1I7E
Type: protein
Length: 237 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tubby protein
UniProt: P50586
Ligands: IBS
Pockets: 2 · best druggability 0.54

Structure

x-ray diffraction · 1 distinct chain · 14% helix, 40% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Tubby protein	protein	237	14% helix, 40% strand	P50586

Ligands and binding sites

IBS · L-alpha-glycerophospho-D-myo-inositol-4,5-bis-phosphate · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	137	0.54	0.81	20	empty
2	59	0.28	0.74	16	empty

Compared structures

1I7E · C-Terminal Domain Of Mouse Brain Tubby Protein bound to Phosphatidylinositol… · the same entry in another collection · chain A against A, TM-score 1.00
P50586 · AlphaFold monomer V2.0 prediction for tubby protein (P50586) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P50586
Elsewhere: RCSB PDB 1I7E · PDBe 1I7E · UniProt P50586

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