MolNFT v1 · #97855 · protein + RNA
Structure of human argonaute-1 let-7 complex
4KRF · Protein argonaute-1: “Structure of human argonaute-1 let-7 complex”. X-ray diffraction, 7 pockets (best druggability 0.83). MolNFT v1 #97855 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4KRF
- Type
- protein + RNA
- Length
- 829 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein argonaute-1; RNA (5'- R(P*UP*GP*AP*GP*GP*UP*AP*GP*UP*AP*GP*GP*UP*UP*GP*UP*AP*UP*AP…
- UniProt
- Q9UL18
- Pockets
- 7 · best druggability 0.83
Structure
x-ray diffraction · 2 distinct chains · 31% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein argonaute-1 | protein | 817 | 31% helix, 28% strand | Q9UL18 |
| R | RNA (5'- R(P*UP*GP*AP*GP*GP*UP*AP*GP*UP*AP*GP*GP*UP*UP*GP*UP*AP*UP*AP*GP*UP*U) -3') | rna | 12 | — | — |
Pockets
7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 974 | 0.83 | 0.85 | 96 | empty |
| 2 | 221 | 0.57 | 0.79 | 32 | empty |
| 3 | 136 | 0.46 | 0.77 | 20 | empty |
| 4 | 93 | 0.44 | 0.79 | 22 | empty |
| 5 | 120 | 0.39 | 0.75 | 19 | empty |
Interfaces
1 interface between chains.
- A–R · 1924 Ų buried · 63 hydrogen bonds · protein-nucleic
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UL18
- Elsewhere: RCSB PDB 4KRF · PDBe 4KRF · UniProt Q9UL18
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