MolNFT v1 · #97481 · protein

Crystal structure of a glutathione transferase family member from ralstonia solanacearum, target efi-501780, with bound gsh coordinated to a zinc ion, ordered active site

4KF9 · Glutathione S-transferase protein: “Crystal structure of a glutathione transferase family member from ralstonia solanacearum, target efi-501780…”. X-ray diffraction, 2 ligands (GSH, ZN), 2 pockets (best druggability 0.79). MolNFT v1…

PDB: 4KF9
Type: protein
Length: 318 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Glutathione S-transferase protein
EC: 2.5.1.18
Ligands: GSH, ZN
Pockets: 2 · best druggability 0.79

Structure

x-ray diffraction · 1 distinct chain · 45% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Glutathione S-transferase protein (EC 2.5.1.18)	protein	318	45% helix, 17% strand	—

Ligands and binding sites

GSH · Glutathione · ligand · chains A
ZN · Zinc ion · metal · 4 copies · chains A
ACT · Acetate ion · additive · 3 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	489	0.79	0.86	63	ZN, GSH, ACT
2	160	0.44	0.75	23	empty

Compared structures

4KF9 · Crystal structure of a glutathione transferase family member from ralstonia solanacearum… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 4KF9 · PDBe 4KF9

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