MolNFT v1 · #97377 · protein
MSTING
4KC0 · Stimulator of interferon genes protein: “MSTING”. X-ray diffraction, 5 pockets (best druggability 0.87). MolNFT v1 #97377 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4KC0
- Type
- protein
- Length
- 360 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Stimulator of interferon genes protein
- UniProt
- Q3TBT3
- Pockets
- 5 · best druggability 0.87
Structure
x-ray diffraction · 2 distinct chains · 41% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Stimulator of interferon genes protein | protein | 182 | 41% helix, 20% strand | Q3TBT3 |
| B | Stimulator of interferon genes protein | protein | 178 | 40% helix, 21% strand | Q3TBT3 |
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 480 | 0.87 | 0.94 | 46 | empty |
| 2 | 129 | 0.47 | 0.78 | 26 | empty |
| 3 | 83 | 0.42 | 0.79 | 20 | empty |
| 4 | 64 | 0.30 | 0.74 | 10 | empty |
| 5 | 55 | 0.27 | 0.74 | 11 | empty |
Interfaces
1 interface between chains.
- A–B · 1334 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q3TBT3
- Elsewhere: RCSB PDB 4KC0 · PDBe 4KC0 · UniProt Q3TBT3
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