MolNFT v1 · #97364 · protein

Structure of mtb rnap beta subunit B1 and B2 domains

4KBJ · DNA-directed RNA polymerase subunit beta: “Structure of mtb rnap beta subunit B1 and B2 domains”. X-ray diffraction, 7 pockets (best druggability 0.73). MolNFT v1 #97364 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4KBJ
Type: protein
Length: 770 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: DNA-directed RNA polymerase subunit beta
EC: 2.7.7.6
UniProt: P0A680
Pockets: 7 · best druggability 0.73

Structure

x-ray diffraction · 2 distinct chains · 39% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	DNA-directed RNA polymerase subunit beta (EC 2.7.7.6)	protein	384	39% helix, 23% strand	P0A680
B	DNA-directed RNA polymerase subunit beta (EC 2.7.7.6)	protein	386	38% helix, 24% strand	P0A680

Pockets

7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	932	0.73	0.77	62	empty
2	650	0.72	0.79	58	empty
3	65	0.39	0.79	19	empty
4	78	0.35	0.76	15	empty
5	58	0.34	0.78	20	empty

Interfaces

1 interface between chains.

A–B · 1106 Å² buried · 12 hydrogen bonds · protein-protein

Compared structures

4KBJ · Structure of Mtb RNAP Beta subunit B1 and B2 domains · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P0A680
Elsewhere: RCSB PDB 4KBJ · PDBe 4KBJ · UniProt P0A680

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