MolNFT v1 · #97361 · protein

Two different open conformations of the helicase core of the RNA helicase hera

4KBF · Heat resistant RNA dependent ATPase: “Two different open conformations of the helicase core of the RNA helicase hera”. X-ray diffraction, 3 ligands (AMP, NA, SO4), 4 pockets (best druggability 0.69). MolNFT v1 #97361 on GenesisL1…

PDB: 4KBF
Type: protein
Length: 730 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Heat resistant RNA dependent ATPase
UniProt: Q72GF3
Ligands: AMP, NA, SO4
Pockets: 4 · best druggability 0.69

Structure

x-ray diffraction · 1 distinct chain · 41% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Heat resistant RNA dependent ATPase	protein	365	41% helix, 18% strand	Q72GF3

Ligands and binding sites

AMP · Adenosine monophosphate · ligand · chains A
NA · Sodium ion · metal · 2 copies · chains A
SO4 · Sulfate ion · ion · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	549	0.69	0.79	58	empty
2	179	0.49	0.77	28	empty
3	74	0.37	0.78	20	empty
4	105	0.33	0.72	14	empty

Interfaces

1 interface between chains.

A–B · 993 Å² buried · 9 hydrogen bonds · protein-protein

Compared structures

4KBF · two different open conformations of the helicase core of the RNA helicase Hera · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q72GF3
Elsewhere: RCSB PDB 4KBF · PDBe 4KBF · UniProt Q72GF3

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