MolNFT v1 · #96963 · protein

Angiopoietin-2 fibrinogen domain tag mutant

4JZC: “Angiopoietin-2 fibrinogen domain tag mutant”. X-ray diffraction, 1 pocket (best druggability 0.37). MolNFT v1 #96963 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4JZC
Type: protein
Length: 218 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Angiopoietin-2
UniProt: O15123
Pockets: 1 · best druggability 0.37

Structure

x-ray diffraction · 1 distinct chain · 15% helix, 33% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Angiopoietin-2	protein	218	15% helix, 33% strand	O15123

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	83	0.37	0.76	17	empty

Modifications

Observed in the structure: 3 disulfide (disulfide).

Compared structures

4JZC · Angiopoietin-2 fibrinogen domain TAG mutant · the same entry in another collection · chain A against A, TM-score 1.00
O15123 · AlphaFold monomer V2.0 prediction for angiopoietin-2 (O15123) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O15123
Elsewhere: RCSB PDB 4JZC · PDBe 4JZC · UniProt O15123

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