MolNFT v1 · #96642 · protein

5A resolution structure of proteasome assembly chaperone HSM3 in complex with a C-terminal fragment of RPT1

4JPO · DNA mismatch repair protein HSM3: “5A resolution structure of proteasome assembly chaperone HSM3 in complex with a C-terminal fragment of RPT1”. X-ray diffraction, 10 pockets (best druggability 0.66). MolNFT v1 #96642 on GenesisL1…

PDB: 4JPO
Type: protein
Length: 1,047 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: DNA mismatch repair protein HSM3; 26S protease regulatory subunit 7 homolog
UniProt: P38348, P33299
Pockets: 10 · best druggability 0.66

Structure

x-ray diffraction · 4 distinct chains · 65% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	DNA mismatch repair protein HSM3	protein	452	67% helix, 0% strand	P38348
B	DNA mismatch repair protein HSM3	protein	447	64% helix, 0% strand	P38348
C	26S protease regulatory subunit 7 homolog	protein	74	62% helix, 3% strand	P33299
D	26S protease regulatory subunit 7 homolog	protein	74	64% helix, 3% strand	P33299

Pockets

10 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	377	0.66	0.80	46	empty
2	146	0.64	0.86	20	empty
3	368	0.62	0.78	40	empty
4	78	0.60	0.89	12	empty
5	304	0.58	0.77	31	empty

Interfaces

5 interfaces between chains.

A–C · 1200 Å² buried · 19 hydrogen bonds · protein-protein
B–D · 1039 Å² buried · 18 hydrogen bonds · protein-protein
A–D · 536 Å² buried · 7 hydrogen bonds · protein-protein
A–B · 310 Å² buried · 3 hydrogen bonds · protein-protein
B–C · 277 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

4JPO · 5A resolution structure of Proteasome Assembly Chaperone Hsm3 in complex with a… · the same entry in another collection · chain D against D, TM-score 1.00
P38348 · AlphaFold monomer V2.0 prediction for DNA mismatch repair protein HSM3 (P38348) · a predicted model of the same protein · chain A against A, TM-score 0.96
P33299 · AlphaFold monomer V2.0 prediction for 26S proteasome regulatory subunit 7 homolog (P33299) · a predicted model of the same protein · chain D against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P38348
Every structure of UniProt P33299
Elsewhere: RCSB PDB 4JPO · PDBe 4JPO · UniProt P38348 · UniProt P33299

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