MolNFT v1 · #96595 · protein
Crystal structure of the human NUP49CCS2+3* NUP57CCS3* complex 1:2 stoichiometry
4JO9 · Nucleoporin P54: “Crystal structure of the human NUP49CCS2+3* NUP57CCS3* complex 1:2 stoichiometry”. X-ray diffraction, 1 pocket (best druggability 0.34). MolNFT v1 #96595 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 4JO9
- Type
- protein
- Length
- 161 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nucleoporin P54; Nucleoporin P58/P45
- UniProt
- Q7Z3B4, Q9BVL2
- Pockets
- 1 · best druggability 0.34
Structure
x-ray diffraction · 3 distinct chains · 86% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nucleoporin P54 | protein | 38 | 89% helix, 0% strand | Q7Z3B4 |
| B | Nucleoporin P58/P45 | protein | 85 | 89% helix, 0% strand | Q9BVL2 |
| C | Nucleoporin P54 | protein | 38 | 74% helix, 0% strand | Q7Z3B4 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 87 | 0.34 | 0.74 | 21 | empty |
Interfaces
3 interfaces between chains.
- A–B · 958 Ų buried · 2 hydrogen bonds · protein-protein
- B–C · 601 Ų buried · 3 hydrogen bonds · protein-protein
- A–C · 533 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 4JO9 · Crystal structure of the human Nup49CCS2+3* Nup57CCS3* complex 1:2 stoichiometry · the same entry in another collection · chain A against A, TM-score 1.00
- Q7Z3B4 · AlphaFold monomer V2.0 prediction for nucleoporin P54 (Q7Z3B4) · a predicted model of the same protein · chain A against A, TM-score 0.86
- Q9BVL2 · AlphaFold monomer V2.0 prediction for nucleoporin P58/P45 (Q9BVL2) · a predicted model of the same protein · chain B against A, TM-score 0.56
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7Z3B4
- Every structure of UniProt Q9BVL2
- Elsewhere: RCSB PDB 4JO9 · PDBe 4JO9 · UniProt Q7Z3B4 · UniProt Q9BVL2
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