MolNFT v1 · #96572 · protein
A unique spumavirus gag N-terminal domain with functional properties of orthoretroviral matrix and capsid
4JNH · Gag polyprotein: “A unique spumavirus gag N-terminal domain with functional properties of orthoretroviral matrix and capsid”. X-ray diffraction, 2 pockets (best druggability 0.46). MolNFT v1 #96572 on GenesisL1: 3D structure…
- PDB
- 4JNH
- Type
- protein
- Length
- 344 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Gag polyprotein
- UniProt
- P14349
- Pockets
- 2 · best druggability 0.46
Structure
x-ray diffraction · 2 distinct chains · 40% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Gag polyprotein | protein | 171 | 40% helix, 20% strand | P14349 |
| B | Gag polyprotein | protein | 173 | 40% helix, 21% strand | P14349 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 94 | 0.46 | 0.80 | 16 | empty |
| 2 | 81 | 0.41 | 0.78 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 1742 Ų buried · 24 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 12 modified (engineered).
Compared structures
- 4JNH · A unique spumavirus gag N-terminal domain with functional properties of orthoretroviral… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P14349
- Elsewhere: RCSB PDB 4JNH · PDBe 4JNH · UniProt P14349
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